Speaker: Prof. Dr-Ing.Timon Rabczuk, Chair of Computational Mechanics, Bauhaus University Weimar

Time: 9:00-10:00 a.m., July 26, 2023, GMT+8

Venue: 210 No.1 Building, College of Engineering

Abstract:

The use of electric fields as an external stimulus has beeshown to be an effective technique for engineering vesiclo behavior in a wide range of biotechnoloqical applications. Electroporation has been successfully utilized for introducing genes or drugs into cells and cancer treatments. As a powerful cell manipulation method, electric fields have been use in tissue ablation, wound healing, and electroformation and electrofusion of giant vesicles. These important applications have motivated theoretical and computational studies on electrohvdrodvnamics of vesicles in order to cain a betteunderstanding of the variety of membrane responses under the influence of electric and flow fields. In this talk, the work devoted to developing a robust computational framework using isogeometric analysis and the phase-field method to model the morphological evolution of single- and multi-phase biomembranes will be presented. We developed three-dimensional isogeometric analysis formulation for the phase-field constrained optimization problem of morphological evolution of vesicles in electrical fields. The effect of the flexoelectricity and the conductivity ratio of the electrolyte orvesicle equilibrium shape were studied through several 3D numerical examples. We captured sphere-oblate andsphere-prolate shape transitions under varying conductivity ratio.

Biography:

Prof. Timon Rabczuk, Chair Professor of Computational Mechanics, Head of the Institute of Structural Mechanics at Bauhaus-Weimar University Member of the European Academy of Sciences, Member of the EuropearAcademy of Sciences and Arts, and recipient of the Feodor Lynen Awardfrom Alexander von Humboldt Foundation. His research interests are in computational mechanics, biomechanics, machine learning and computational design of advanced materials. He has been solving problems with high strain rate of materials, explosive impact of protectivestructures, fluid-solid interaction and design of nano materials.  He has listed as a Global Highly Cited Scholar by ISI Engineering and Computer Science since 2012. He has published more than 700 papers in international journals, attracting 40,00 citations.

Source: College of Engineering