Speaker: Kunliang Guan, Ph.D.Chair Professor, School of Life Sciences, Westlake University

Time: 13:00 p.m., December 1, 2023, GMT+8

Venue: Deng Youcai Academic Hall, School of Life Sciences, PKU

Abstract: 

The Hippo pathway is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size control, and regeneration. The core of the Hippo pathway consists of a kinase cascade, MST1/2 and LATS1/2, as well as downstream effector transcriptional coactivators YAP and TAZ. The Hippo pathway is tightly regulated by both intrinsic and extrinsic ,signals. Dysregulation of the Hippo pathway is frequently found in and contributes to cancer. I will review the current understanding of Hippo signaling and discuss our recent studies revealing the Hippo pathway regulation by phosphoinositides and unexpected role of YAP in small cell lung cancer.

Source: School of Life Sciences, PKU