Speaker: Dr. Qian Yin, University of Texas at Austin

Time: 09:00 a.m., December 6, 2023, GMT+8

Venue: CB101, Chemistry Building, PKU

Abstract: 

The immune system consists of two parts: innate immunity and adaptive immunity. T cells and B cells in the adaptive immune system are two major players to mount an antigen-specific defense and offer long-term protection.However, due to the immune tolerance and immunodominance mechanisms, some T cells and B cells can recognize the antigens but couldn't develop effective immune responses. My research focus is using synthetic biomaterials to engineer the innate immune system and unlock the non-responsive adaptive immune repertoire for new cancer immunotherapies and infectious disease vaccines. In this seminar, two examples illustrating my research work will be described. In the first example, I develop a toll-like receptor 7 agonist-based nanoparticle (TLR7-NP) adjuvant to alter germinal center (GC) signaling and induce high levels of cross-reactive antibody responses to multiple heterologous viral variants of influenza and SARS-CoV-2. The second example is to design a nanoparticle platform to reverse the anergy of tumor infiltrating self-specificCD8+ T cells for creating a new and effective immunotherapeutic strategy for treating broad cancer patients.

Source: College of Chemistry and Molecular Engineering, PKU