Speaker: Prof. Yan Zhao, Department of Chemistry, Iowa State University

Time: 08:30 a.m., December 13, 2023, GMT+8

Venue: CB101, Chemistry Building, PKU

Abstract: 

Creation of synthetic receptors to bind biologically important molecules in water with high affinity and specificity is challenging, but can be achieved through molecular imprinting within cross-linkable surfactant micelles. The resulting molecularly imprinted nanoparticles (MINPs) are characterized by the discrete binding sites and great resemblance to protein receptors in their nanodimension, water-solubility, a functionalizable exterior, and easily accessible, tailor-made hydrophobic binding pockets. MINPs could be made to recognize peptides by their amino acid sequence, side chains, and chain length.They distinguish monosaccharides by their number and orientation of hydroxyls and oligosaccharides by their sugar building blocks, a/ß glycosidic linkage, and chain length. When installed with catalytic functionalities in the active sites, they could perform highly selective chemical transformations as synthetic enzymes.

Source: College of Chemistry and Molecular Engineering, PKU