Speaker: Prof. Josef Parvizi, Neurology & Neurological Sciences, Stanford University 

Time: 13:00-14:30 p.m., March 26, 2024, GMT+8

Venue: Room 1113, Wangkezhen Building, PKU 

Abstract: 

For any brain to operate, populations of neurons across anatomical structures must coordinate their activity within milliseconds. To date, our understanding of the dynamics of cross regional interactions  stems from neuroimaging methods that provide valuable insights into the functional architecture of the human brain in the ultra slow temporal scale and examining the fast interactions and truly causal connections across regions remains limited, if not prohibitive.   In our research endeavors, we strive to build upon existing neuroimaging by investigating the dynamics of cross-regional communication on a subsecond scale using simultaneous intracranial recordings across various brain regions under different experimental conditions. To assess and quantify causal effective connectivity across these regions, we employ repeated single electrical pulse stimulations. While simultaneous recordings across spatially distributed brain regions provide a precise lens on human circuit-level dynamics (at the level of discrete neuronal populations) stimulation measures provide unique causal information in humans regarding the effect of stimulating one neuronal population on the activity of other sites as the dynamics of relationship between that site and others. In this lecture, I will present novel data regarding cross regional dynamics of activity during memory encoding and retrieval.

Source: McGovern Institute for Brain Research at PKU