Speaker: Zhang Shicheng, PKU

Time: 14:00 p.m., March 14, 2024, GMT+8

Venue: B117, Research Complex #2, PKU

Abstract: 

The brain, intricately linked with processes such as thinking, behavior, and emotions, stands out as one of the most complex and enigmatic organs in the human body. Neuroscience research not only enhances our understanding of the mechanisms underlying neuropsychiatric disorders but also plays a pivotal role in the advancement of pertinent drugs and treatment methodologies. The speaker's primary focus lies in G protein-coupled receptors, utilizing research techniques such as molecular and structural pharmacology.This research encompasses the identification and validation of novel targets, as well as the discovery and optimization of molecular probes and lead compounds. Furthermore, the study involves the development and expansion of chemogenetic tools. In this presentation, the speaker will elucidate strategies for investigating G protein-coupled receptors that have been underexplored or insufficiently studied, using the example of the serotonin 5A receptor. Additionally, the speaker will briefly outline the design principles and operational mechanisms of the DREADD(Designer Receptors Exclusively Activated by Designer Drugs)-based chemogenetic system, providing insights into its subsequent expansion and development.

Source: School of Life Sciences, PKU