Speaker: Dr. Wang Jue, University of Wisconsin–Madison

Time: 14:00-15:00 p.m., April 15, 2024, GMT+8

Venue: Room B117, Research Complex #2, PKU  

Abstract: 

Bacterial stress-signaling alarmones are important components of a protective network against diverse stresses such as nutrient starvation and anti-biotic assault. (p)ppGpp has well- documented regulatory roles in gene expression and protein translation. Our work has highlighted another key function of (p)ppGpp: inducing rapid and coordinated changes in cellular metabolism by regulating enzymatic activities, especially those involved in purine nucleotide synthesis. Failure of metabolic regulation by (p)ppGpp results in the loss of coordination between metabolic and macromolecular processes, leading to cellular toxicity. I will discuss classical and emerging themes in nucleotide signaling, including oligomerization and allostery along with metabolic interconversion and crosstalk, illustrating how they allow optimized bacterial adaptation to their environmental niches.

Source: Biomedical Pioneering Innovation Center, PKU