Speaker: Danyu Lin(The University of North Carolina at Chapel Hill)

Time: 14:00-15:00 p.m., May 30, 2024, GMT+8

Venue: Rm 225, Siyuan Hall, Zhihua Building, PKU

Abstract: 

Approximately 800 million COVID-19 cases and 7 million COVID-19 deaths have been reported to the World Health Organization thus far.  Vaccination is a major tool to combat the COVID-19 pandemic, but its effectiveness wanes over time and tends to be lower against new SARS-CoV-2 variants. The knowledge about the waning effects of vaccination can guide boosting strategies. In a series of papers published in New England Journal of Medicine, JAMA and The Lancet, we reported several large cohort studies using COVID-19 vaccination and case surveillance data from the states of North Carolina and Nebraska, as well as electronic health records from the Cleveland Clinic Health System. We developed a novel statistical framework to evaluate the time-varying effects of the three generations of COVID-19 vaccines produced in the United States on infections with different SARS-CoV-2 variants and on severe outcomes (hospitalization and death). Our findings have been used by the World Health Organization and the U.S. Centers for Disease Control and Prevention and Food and Drug Administration and reported by The New York Times, The Washington Post and NBC News.

Source: School of Mathematical Sciences, PKU