Speaker: Li Long (Peking University, School of Life Sciences)

Time: 16:00 - 17:00 p.m., Apr 1, 2025, GMT+8

Venue: Rm B117, Research Complex #2, PKU

Abstract: 

After ribosome translation, proteins need to be transported to different locations for proper functioning. Organelle membranes pose major physical barriers for protein movement in cells, including the lipid membranes of the endoplasmic reticulum (ER), lysosomes, and mitochondria. Cells have evolved a variety of sophisticated protein translocation systems to facilitate the movement of proteins across or into lipid membranes. These translocation systems are highly efficient in creating cross-membrane pathways for proteins while preventing the movement of small molecules, ions, and water. Defects in protein translocation have been associated with numerous human diseases. In this talk, I will first introduce the general concepts of protein translocation systems, using the classic Sec complexes in the secretory pathway as an example. Then, I will discuss the recent 're-discovery' of protein translocases for mitochondrial protein import and its implications for the general working mechanisms of protein translocation.
Source: College of Future Technology, PKU