Peking University, August 19, 2024: In a remarkable achievement for China's scientific community, Prof. Deng Hongkui of Peking University has been awarded the Future Science Prize 2024 in Life Sciences. His groundbreaking discoveries in chemically converting somatic cells into pluripotent stem cells have earned him this honor. His innovative research has paved the way for new developments in regenerative medicine and holds great potential for organ replacement and cell therapy improvements.

Prof. Deng Hongkui wins Future Science Prize 2024

Among Prof. Deng's other revolutionary contributions is the creation of Human CiPS (Chemically Induced Pluripotent Stem) cells, a new breed of human pluripotent stem cell production method. In contrast to conventional techniques, which frequently depend on intricate and dangerous genetic alterations, Deng's method reprograms adult cells using tiny chemical compounds. This approach offers more precise cell reprogramming and a wider range of clinical applications; it is safer as well as more effective. 
 

Graphic: Toward a more rapid and efficient system for chemical reprogramming of human cells 

"How to reverse the clock of life is one of the most important scientific questions in the field of stem cells and regenerative medicine," said Prof. Deng. His team's breakthrough in reprogramming human cells by chemical tiny molecules has overcome earlier technological barriers, bringing a new outlook for the treatment of diseases including HIV and diabetes. For example, his research team has shown that human induced pluripotent stem cells (Human CiPS cells) may effectively develop into pancreatic islets, offering a possible novel approach to treating diabetes. 

Prof. Deng’s team published “Human pluripotent stem cell-derived pancreatic islets improve diabetes in nonhuman primates” in Nature Medicine. 

With the recognition from the Future Science Prize, Prof. Deng is placed among the ranks of China’s leading scientists and highlights the growing prominence of Chinese research in the global scientific community. His work signifies China's potential to become a global leader in the life sciences and also marks a significant advancement in regenerative medicine.
 

Prof. Deng at laboratory (Credit: Science China Press)

Prof. Deng concluded his journey by saying, "I am confident in China's future progress in researching the 'big questions,' and the center of life sciences will gradually shift to China." Prof. Deng inspires the next generation of scientists to remain optimistic, persistent, and brave in the face of scientific challenges as he continues to push the boundaries of scientific research.

Prof. Deng with his research team

Life has to continue expanding like a seed, just like Prof. Deng's study does. His views work as a tribute to the never-ending pursuit for knowledge and the scientific community's boundless capacity to push the frontiers of human knowledge.

Written by: Aden Tan
Edited by: Dennis Meng
Source: PKU News (Chinese)